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ONC
ACCE-researched

BeOne Medicines Ltd. American Depositary Shares (ONC) fair value

Healthcare · Biotechnology · NASDAQ · United States
$377.63-1.21%
Market cap $43.5BNext earnings 2026-11-05Updated Oct 20, 2026
Add earnings to calendarGoogle
Our verdict
Trades 148% above our fair value
Price
$377.63
Model fair valueConfidence: good
$152
Model range
$120 to $184
Fair value $152
Price $378
2 models fit BeOne Medicines Ltd. American Depositary Shares and they disagree: 0 of 2 land within 15% of the average. The price is above every model.
Two or more of our models back this value.
Large premium(i)Bronze42
Valued as a growth company: Discounted cash flow, P/E comparison, and EV/EBITDA comparison.
ACCE opinionBeOne Medicines Ltd. American Depositary Shares (ONC)
Fair value (2 models)
$152
ACCE price target
$362
Rating
Overvalued
Horizon
12 months
Fair value published on 20 Oct 2026, 16:04 CEST; previously $177 since 16 Oct 2026, 00:00 CEST.
ACCE price target published on 21 Sept 2026, 00:00 CEST.
Rating published on 20 Oct 2026, 16:04 CEST.
Price used: $378 at the close on 23 Oct 2026, 22:00 CEST.
Models: Discounted cash flow and P/E comparison.
Fair value: the average of the applicable valuation models (discounted cash flow, multiples, residual income, dividend discount, shareholder yield), each run on the latest financial statements and the market price shown. Opinion columns (fair value, target, rating) are shown apart from the data. Full methodology: acceinvestments.com/data/how-we-value-stocks
Full methodology
Conflicts of interest: The author holds no personal position in this security. General statement
Produced by ACCE Investments (acceinvestments.com)
Data
Price vs fair value
148.4% above
-59.7% to fair value
ACCE score
69
out of 100
Analysts
96% buy
27 covering
P/E
69.1x
forward 35.2x
1-year return
+21.8%
Dividend yield
0.00%

BeOne Medicines Ltd. American Depositary Shares in four questions

Plain answers, details below
Free accounts get 5 full stock pages a month, including the four answers.
OverviewAsk ACCEValuationQualityAnalystsSmart MoneyCompareNews and Record

Overview

ACCE thesis

BeOne Medicines (ONC) is a Swiss-domiciled oncology company selling BRUKINSA, a BTK inhibitor for blood cancers, and developing a pipeline of targeted and immuno-oncology candidates. The moat rests on that franchise: an 88.9% gross margin shows how much of each dollar is pure pricing power once a drug is on the market. Revenue growth of 29.6% is the number to underwrite, since it signals BRUKINSA is still gaining share and new indications and geographies are feeding through. A 19.1% operating margin says the company is now earning real operating profit rather than only booking sales, though a trailing P/E of 62.7 against a forward P/E of 34.2 means the market is already pricing in a sharp earnings ramp. At a 39.9B USD market cap and 14.7% ROE, the case for a deeper look depends on whether margin expansion and pipeline readouts can close that gap.

AI-assisted·How I use AIWritten Oct 13, 2026
⚠ Investor warnings · 3 flagsAI-assisted·How I use AI
  • high
    Valuation disconnect from quality
    P/E 63.4 and EV/EBITDA 34.3 are steep for a biotech, even with 166.7% earnings growth.
  • high
    Heavy insider selling
    Last 10 disclosures show $123.43M in insider sales against $0 in buys. Insiders are exiting despite strong fundamentals, a classic warning signal.
  • moderate
    Valuation score collapse
    V score is 22/100, indicating the model sees the stock as significantly overvalued relative to intrinsics. Growth is real but price has run ahead.

AI research notes

AI-assisted·How I use AIWritten Oct 11, 2026 · figures from 2026-06-30 · prices to Oct 23, 2026
Why it could do well
  • BeOne has grown revenue 55.7% annually over five years, far outpacing typical healthcare peers and validating its commercial execution.
  • The company generated $879M in free cash flow last year while maintaining a healthy 0.40 debt-to-equity ratio.
  • BeOne beat earnings expectations by 46.4% in the latest quarter, and 96% of analysts rate the stock Buy or Strong Buy.
Why it could disappoint
  • Consensus fair value sits 42.9% below the current share price, with two of three valuation models supporting that lower target.
  • Share count grew 7.8% last year while free cash flow yield is only 2.2%, limiting shareholder returns from current cash generation.
Each chip shows the exact figure and where it comes from. A claim without a source is not published.

Next results

Nov 5, 2026
We update the fair value about 2 days after the results, once the new figures are filed.Add to calendarGoogle

Walk me through this stock

Plain-English pros, cons, and what to watch. Pro feature.

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Valuation

INVESTOR
Where ONC's valuation models land
Price
$377.63
Model fair value
$152
Model range
$120 to $184
Fair value $152
Price $378
The price is above the whole model range.
Model
Fair value
Upside
Discounted cash flow
EV/EBITDA comparison
P/E comparison
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Quality

INVESTOR
Quality and conviction INVESTOR FEATURE

The full quality picture: a reason under every score, how the scores moved, and the conviction breakdown.

  • +A plain reason under every score
  • +Conviction breakdown and growth / value / quality / momentum scores
  • +Score history: how each score moved over time

Analysts

Wall Street consensus

Bullish96% buy · 27 covering analysts
● Strong buy 19● Buy 7● Hold 1● Sell 0● Strong sell 0
Analyst intelligence INVESTOR FEATURE

The full analyst picture: the price-target distribution against the current price, forward consensus estimates, and how ACCE's own models compare.

  • +Price-target low / average / high vs the current price, with implied upside
  • +Forward revenue and EPS consensus by fiscal year
  • +ACCE fair-value models lined up against the Street

Smart Money

PRO

In one line

Trades are only made public after a delay. We show the delay so you know how old the news is.

Company insiders
No trades filed
Last 90 days
Congress
No trades filed
Last 180 days
Average delay
No trades filed
From trade to public filing
Do politicians beat the market? Our backtest →
Smart money tracking PRO FEATURE

Follow the informed money: 13F position changes, insider and Congress trades, and 13D activist filings.

  • +Quarter-over-quarter institutional position changes
  • +Every insider and Congress trade, with how late it was disclosed
  • +Active 13D activist filings and top holders

Compare

Where it sits vs peers

News and Record

Press releases mentioning this company

Recent performance

1 week
+2.3%
1 month
+3.5%
3 months
+15.9%
6 months
+25.5%
YTD
+24.3%
1 year
+21.8%

SEC filings

Recommendation history, last 12 months

DateTypeNewPreviousPrice
20 Oct 2026, 16:04 CESTRatingOvervaluedfirst publication$370
20 Oct 2026, 16:04 CESTFair value$152$177$370
16 Oct 2026, 00:00 CESTFair value$177$202$351
11 Oct 2026, 00:00 CESTFair value$202$179$354
29 Sept 2026, 00:00 CESTFair value$179$184$361
21 Sept 2026, 00:00 CESTACCE price target$362first publication$351
15 Sept 2026, 00:00 CESTFair value$184$188$347
12 Sept 2026, 00:00 CESTFair value$188$191$342
31 Aug 2026, 00:00 CESTFair value$191$350$367
21 Aug 2026, 00:00 CESTFair value$350$203$375

This analysis is not personalised investment advice and does not take your situation, objectives or risk tolerance into account. ACCE Investments is not an authorised investment firm.

Investing in shares carries a risk of losing capital. The value of an investment can go down as well as up.

Valuation horizon: 12 months from the publication date.

Conflicts of interest. ACCE Investments is operated by Adrien Chantreuil, who may hold personal positions in the securities analysed. Positions are declared on each security. ACCE receives no payment from the companies analysed or from any intermediary for this analysis.

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Snapshot

Growth88Value20Quality76Momentum90Total69
Valuation
Trailing P/E
69.1x
Forward P/E
35.2x
PEG
0.77
P/B
7.98x
EV / Revenue
6.3x
Book value/sh
$45.78
Enterprise value
$38.3B
Profitability
ROE
14.7%
FCF yield
2.17%
ROIC
3.7%
Health and risk
Debt / equity
0.46
Dividend yield
0.00%
Beta
0.61

Price

+21.5% · 1Y

Ask anything about ONC

Answered from BeOne Medicines Ltd. American Depositary Shares fundamentals + recent valuations. Every number shows its source and date.

This stock Peer Peer median weaker → stronger
P/Ebetter than 0% of peers
low 24.1x69.1xhigh 69.1x
ROEbetter than 50% of peers
low -79%15%high 97%
Div yieldbetter than 50% of peers
low 0.0%0.0%high 2.1%

Peers

Prices Oct 23, 2026
CompanyPriceFair valuevs fair valueP/EROEQualityScore
ONC BeOne Medicines Ltd. American Depositary Shares$377.63$152148% above69.1x14.7%7669
RVMD Revolution Medicines Inc. Common Stock$187.69----79.1%3136
RPRX Royalty Pharma plc Class A Ordinary Shares $63.75$641% below33.9x14.0%7768
ARGX argenx SE American Depositary Shares$875.76$399119% above30.3x23.6%9174
UCB.BR UCB€259.10€14381% above24.1x20.6%9576
ALNY Alnylam Pharmaceuticals Inc. Common Stock$227.28$14458% above37.8x96.6%7949
CSL.AX CSLA$196.14A$16023% above--15.8%5252

Sector report card

Where ONC ranks against its sector peers on each metric.

Computing percentiles…
  • Business Wire•Sep 1, 2026
    BeOne Medicines to Present at the Morgan Stanley Annual Global Healthcare Conference
  • Business Wire•Aug 31, 2026
    BeOne Medicines Announces Voluntary Agreement with U.S. Government to Expand Access to Innovative Cancer Medicines
  • Business Wire•Aug 31, 2026
    BeOne Medicines Announces New Phase 3 Survival Data Reinforcing Benefit of ZIIHERA-Containing Regimens in First-Line HER2+ Gastroesophageal Cancer
10 more press releases · full archive on Investor+.INVESTOR
40 filings
October 2026
Oct 15
Form 4Insider transactionPeriod 2026-10-13
View on SEC →
Oct 2
Form 4Insider transactionPeriod 2026-09-30
View on SEC →
September 2026
Sep 30
Form 4Insider transactionPeriod 2026-09-28
View on SEC →
37 more filings + AI summaries on Investor+.INVESTOR